apalutamide will lower the extent or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with prescription drugs that are CYP3A4 substrates can lead to lower publicity to these remedies.Utilizing this medication with any of the n